How to solve the problem of industrialization of algae oil DHA？

Docosahexaenoic acid (DHA) is an important ω-3 long-chain polyunsaturated fatty acid. It is crucial to human health issues such as the intellectual and visual development of infants and young children, and the prevention of cardiovascular and cerebrovascular diseases. In recent years, it has been widely used in food, healthcare products, and pharmaceutical industries.

The source of DHA was fish oil products. The quality was not only affected by the marine ecological environment, but also the ethyl ester DHA formed during the processing was not conducive to human absorption. At the same time, DHA oil derived from fish oil contains a high content of EPA, and infants, adolescents, pregnant women, and other groups should reduce their intake, which is contrary to the goal of DHA's widely used maternal and infant products. With the increasing development of biotechnology, DHA produced by fermentation of Schizochytrium not only meets the needs of environmentally friendly ecological development, but also has stable product quality, safety, and reliability, and has broad application prospects.

There are many difficulties in the industrialization process of Schizochytrium to produce DHA.

① Bacteria are the key factor in the fermentation industry. Schizochytrium comes from the deep sea. Compared with ordinary bacteria, it is more difficult to grow and develop. Its strain acquisition, screening and optimization, fermentation process control, and processing technology are all difficulties that need to be overcome;

② The growth and development of Schizochytrium are relatively special to ordinary bacteria. It takes more effort to ensure the stability of good varieties than to select them. It not only requires high-difficulty breeding technology but also requires a high sample volume of fermentation practice process cooperation;

③ Due to the characteristics of DHA polyunsaturated fatty acids, most of the odorous substances in algae are fat-soluble, and few domestic companies integrate biological fermentation technology and functional oil extraction technology, which leads to the defects of DHA algae oil such as easy oxidation and strong odor that need to be solved urgently;

④ Matching equipment is the foothold of biomanufacturing industrialization. Equipment advantage is product advantage. Equipment is the last step of biotechnology and the first step of biotechnology industrialization. Designing matching equipment with scale effect and supporting the subsequent development of the industry is the most difficult of all biotechnology industrialization.

HSF has a professional R&D team that was one of the first in China to industrialize plant sterol esters and natural vitamin E. It has built a scientific-technological-industrialized R&D innovation system and has now developed into a complete organization with two departments, eight project teams, and more than 40 people with independent R&D capabilities. It is an important support for Haisfu Biological's exploration and innovation in the synthetic biology industry.

The R&D innovation system of science, technology, and industrialization

1. One in a million high-quality strains. Since the establishment of the HSF Microbiology Laboratory in 2012, the team has been committed to strain screening and fermentation technology. In 2016, from 218 original strains at home and abroad, after thousands of experiments, they successfully isolated the high-DHA-producing Schizochytrium HSc-01. The batch growth is stable, the bacteria are uniform and full in color, and the total DHA content is as high as 70%.

2. The refined fermentation process. While screening strains, the team also keeps accumulating experience in fermentation technology and production in experiments. For the development of production processes for iterative strains, the plan has been rebuilt several times in six years, and 32 improvements have been made, large and small, and finally, the fermentation and production processes have been confirmed.

3. High-quality products of large integrators. As a professional functional lipid producer in China, HSF has a solid foundation in the production of functional lipids, from natural vitamin E and plant sterol extraction, and separation to esterification. While extracting DHA contained in Schizochytrium, it protects the functional structure of DHA algae oil to the maximum extent, minimizes the impact of aldehydes and ketones in DHA algae oil on flavor, and minimizes the residues in the product and the chemical reactions produced. The functional oil refining technology has a profound foundation, the oil is clear, and the product is pure.

High-purity algae oil, stable batch content, DHA content far exceeds the standards of my country Europe and the United States, and the content of EPA, an "unfriendly ingredient" for infants and young children, is extremely low.

4. National leading large-scale production line. Starting in 2022, HSF has invested 110 million to build a fermentation production line that can perfectly display HSF's R&D technology accumulation. This fermentation production line brings together more than ten years of wisdom from HSF's people. It is a thousand-ton production line that is very suitable for the industrialization of DHA algae oil at this stage, with a high degree of advancement and large scale.

5. Solutions that better understand applications. As a professional manufacturer that understands customers better, HSF has tried its best to extend the application scope of DHA algae oil and build a full range of product platforms for customers. With the support of VegeLipi™ technology, it also launched DHA algae oil powder that is easier to use. Through functional oil encapsulation technology, it perfectly solves the application problems of DHA algae oil, such as poor bioavailability, poor water solubility, easy oxidation, poor taste, difficulty in premixing, and difficulty in transportation. HSF's microencapsulation technology has been continuously honed in actual production and line with higher requirements from customers. It has established a scientific self-developed emulsification system to match the best product customization solutions according to different application requirements.

The HSF R&D team has been deeply engaged in the production strain breeding strategy, high-yield strain breeding, and optimization technology in the development and cooperation for ten years, and has accumulated fermentation technology experience and production experience. With the help of modern biotechnology, information technology, and engineering equipment, the team has achieved multi-link optimization and reconstruction in the fermentation research methods and fermentation processes and gradually solved the problem of DHA algae oil industrialization.

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