What are the benefits of niacinamide?

Source of niacinamide

Niacinamide, also known as vitamin B3, is an important derivative of niacin and is widely distributed in various foods in nature. From abundant animal foods such as meat (especially liver), fish, poultry, and dairy products, to plant foods such as avocados, whole grains (brown rice, oats), mushrooms, and green leafy vegetables, all contain the nourishment of B3. These natural ingredients satisfy our pursuit of deliciousness and invisibly supplement the body with precious B3. Although the human body can synthesize a small amount of Niacinamide through the metabolic pathway of tryptophan, its efficiency is limited and it isn't easy to meet daily needs. Therefore, a balanced diet becomes the key to acquiring this important nutrient.

Conversion of Nicotinamide and NAD+

Inside the human body, nicotinamide undergoes a gorgeous biochemical transformation, transforming into NAD+ (nicotinamide adenine dinucleotide). This change not only unlocks the key to cellular energy metabolism but also makes NAD+ an indispensable core role in life activities. As a catalyst for energy production processes such as the tricarboxylic acid cycle and oxidative phosphorylation, NAD+ not only drives cell energy production but also deeply participates in key life processes such as cell repair, DNA synthesis, and gene expression. It is the cornerstone of maintaining cell health and vitality.

Effects of niacinamide

Since British scientists first discovered the application of niacinamide in the field of sun protection in 1974, its excellent skin care effects have gradually become known to the world. Initially, niacinamide attracted much attention because of its ability to inhibit the transfer of melanin to keratinocytes. Niacinamide can accelerate the metabolism of skin cells and promote the production and renewal of collagen, thereby effectively improving signs of aging such as skin sagging and wrinkles.

In addition to its well-known skin care effects, niacinamide has also shown great potential in the field of health.

Niacinamide and aging

Niacinamide levels decrease with age, which indicates that it is important for metabolic function and age-related diseases. DNA damage accumulates and snowballs with age. Experiments have shown that oral administration of 1000mg of niacinamide per day in the elderly aged 70-80 can increase the level of niacinamide metabolism in muscles, thereby reducing muscle damage in the elderly and reducing the level of circulating inflammatory cytokines.

Nicotinamide and neurological disease

As a potential neuroprotective agent, nicotinamide is a component of the neurotransmitters NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate), which are important in the nervous system. Plays a vital role in its normal function. They participate in redox reactions in the body and provide energy for cell metabolism, thus supporting the normal functioning of the nervous system. Nicotinamide is currently being explored to improve a variety of neurodegenerative diseases. Enhanced nicotinamide supplementation may help improve several major processes related to the pathogenesis of Parkinson's disease, including mitochondrial respiratory dysfunction, neuroinflammation, epigenomic dysregulation, and Increased neural DNA damage. Currently, several clinical trials are exploring the effects of nicotinamide supplementation in patients with Parkinson's disease.

Niacinamide and obesity

Nicotinamide also plays multiple roles in energy metabolism, cell repair, and gene expression. Research shows that in healthy overweight or obese men and women, supplementation with 1000 mg/day of nicotinamide (or its active form such as NR, nicotinamide ribose) for 6 weeks significantly increases NAD+ metabolism in human skeletal muscle NAAD (N-acetyl adenosine diphosphate) and MeNAM (N-methyl nicotinamide) levels. The increase in these metabolites reflects the activation of the NAD+ metabolic pathway, which may promote energy metabolism and fatty acid oxidation in skeletal muscle. Notably, NR supplementation has also been found to increase sleep metabolic rate. Sleep metabolic rate refers to the rate at which the body consumes energy during sleep. By increasing sleep metabolic rate, niacinamide supplementation may help continue to burn calories during the night, further promoting weight loss. This finding provides a new perspective on obesity management by optimizing energy metabolism during sleep to assist in weight loss.

Nicotinamide and cardiovascular disease

NAD+ plays a key role in cellular energy metabolism, redox reactions, and DNA repair. Low NAD+ levels are closely related to the pathogenesis of various cardiovascular diseases. By supplementing NAD+ precursors such as nicotinamide, intracellular NAD+ levels can be significantly increased, thereby enhancing the heart's function and ability to resist damage. Nicotinamide, as a precursor of NAD+, exhibits significant protective effects in cardiovascular diseases by increasing NAD+ levels in the body. In addition, nicotinamide has a significant antioxidant effect, which can scavenge free radicals on blood vessel walls and reduce the damage of free radicals to cardiomyocytes. This antioxidant effect helps protect the structural and functional integrity of heart cells and reduces the risk of heart disease.

White crystalline powder or white needle-shaped crystals, odorless or almost odorless, bitter, slightly hygroscopic.

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