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What is L-alpha GPC

Oct 02, 2021

What is L-alpha GPCAlpha-GPC powder is a choline-containing compound found naturally in the brain as well as in small amounts in foods like meat, fish, eggs, and dairy, also known as choline alfoscerate and alpha-glycerylphosphorylcholine. Alpha-GPC is also a natural phospholipid. Studies and evidence show that alpha-GPC is considered one of the most efficient sources of choline, a fat-soluble member of the B vitamin complex. This indicates that alpha-GPC may effectively increase concentrations of choline.

Alpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of acetylcholine.It is a non-prescription drug in most countries. The FDA determined that intake of no more than 196.2 mg/person/day is considered generally recognized as safe (GRAS).

Alpha-GPC comes from two sources, natural and synthetic. In the market, most of the alpha GPC is the synthetic source.


Alpha-glycerylphosphorylcholine (Alpha-GPC) and caffeine supplementation have been shown to improve mental and physical performance. Alpha-GPC administration increases the release of the neurotransmitter acetylcholine and facilitates learning and memory. In athletes, Alpha-GPC supplementation prevents exercise-induced reductions in choline levels, increases endurance performance and growth hormone secretion. Caffeine has been shown to increase mental focus, acuity and athletic performance, however, contributes to a nervous or anxious feeling.



Alpha-GPC (alpha-glycerophosphocholine) is an all-rounder supplement, as it is both a nootropic and a sports supplement. Alpha-GPC is a water soluble form of choline. Choline occurs naturally in the body in low doses and can also be found in foods such as eggs. In particular, Alpha-GPC is considered the best source of choline because it is the most biodegradable and is capable of increasing choline concentrations both at the brain and system level, as well as protecting the structure of cell membranes. The latter being something that no choline source is capable of achieving. At the brain level, choline plays a fundamental role in cognitive aspects such as the development of memory and learning. Likewise, it is responsible for protecting neurons and maintaining good brain health. So much so that even in the last decade Alpha-GPC has begun to be used with increasing success for the treatment of Alzheimer's and cognitive decline. In the world of nootropics, choline sources play a very important role because they act synergistically with other nootropics to enhance their effects, leading to an amplified improvement of cognitive functions such as memory, concentration or attention. In particular, they work particularly well with the nootropics of the racetam family, such as Piracetam and Aniracetam.