Glutamine is the most abundant amino acid in the human body, and glutamine in the body is mainly an intermediate product of muscle glycogen, blood sugar and tricarboxylic acid cycle. Skeletal muscle, as the main energy metabolism tissue, is the main site for the synthesis and metabolism of endogenous glutamine.
(Image Source：www.issaonline.com）
When the body's catabolism is strengthened, such as high-intensity, long-term exercise, glutamine will play a role as an important carrier of inter-organ ammonia transport and amino acid intermediate metabolism. Supplementation of glutamine is closely related to the body's ability to exercise. At the same time, glutamine is also an important energy supply material for intestinal mucosal cells and some immune cells, and is closely related to the immune system.
Regular physical activity can reduce the risk of chronic diseases and promote body homeostasis, which is essential for maintaining health. However, prolonged or high-intensity physical exercise may promote catabolism, stimulate cells to consume large amounts of glutamine, disrupt body homeostasis, and lead to an imbalance in body defenses.
Glutamine supplementation improves exercise performance
Glutamine, as a precursor of glutamate metabolism in the brain, can freely enter and exit the brain through the blood-brain barrier and play a regulatory role in brain function through the glutamate transmitter system, mediating a series of high-level central nervous activities.
Glutamine and glutamate together as the main excitatory neurotransmitter in the body, are very important to the human body. Studies have shown that after glutamine supplementation, the learning and memory of rats are improved. Supplementation of glutamine can increase the activity of carbon monoxide synthase (YNZ) in the brain and the number of N-methyl-D-aspartate receptors in the hippocampus, which is of great significance for promoting learning and memory, and is conducive to the formation of motor skills. Glutamine is also closely related to exercise capacity.